{"id":1283,"date":"2024-01-18T09:09:29","date_gmt":"2024-01-18T09:09:29","guid":{"rendered":"https:\/\/www.the-nash-education-program.com\/?page_id=1283"},"modified":"2024-01-18T09:09:29","modified_gmt":"2024-01-18T09:09:29","slug":"how-to-diagnose-nash","status":"publish","type":"page","link":"https:\/\/www.the-nash-education-program.com\/what-is-nash\/how-to-diagnose-nash\/","title":{"rendered":"HOW TO DIAGNOSE NASH?"},"content":{"rendered":"\n<p><strong>NASH is a silent disease. Consequently, NASH patients can remain unaware of their liver condition until the&nbsp;disease progresses to more serious and life-threatening stages. Thus, there is a major challenge related to&nbsp;NASH diagnosis: the early identification of patients at risk of progressing to most advanced stages of NASH.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/www.waybackmachinedownloader.com\/scraping\/files\/live\/the-nash-education-program.com_georgenjenga69_yahoo.com_zyrp7w0mtc\/wp-content\/uploads\/2018\/03\/syringe.png\" alt=\"\"\/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">CURRENT GOLD STANDARD: LIVER BIOPSY<\/h4>\n\n\n\n<p>The current gold standard to formally diagnose a patient suspected of having NASH is a liver biopsy. But there&nbsp;exists a real bottleneck which needs to be overcome. Although this invasive test could be performed by&nbsp;hepatologists, the number of these specialists who have both the expertise and comfort to execute, order or&nbsp;interpret a liver biopsy is very low as compared to the number of suspected NASH patients. Besides, liver&nbsp;biopsies are costly surgical acts, and as invasive procedures they present a (minor) risk to the patient, including&nbsp;the possibility of pain and bleeding.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/www.waybackmachinedownloader.com\/scraping\/files\/live\/the-nash-education-program.com_georgenjenga69_yahoo.com_zyrp7w0mtc\/wp-content\/uploads\/2018\/03\/ultrasound.png\" alt=\"\"\/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">OTHER EXISTING DIAGNOSTIC METHODS<\/h4>\n\n\n\n<p>Alternative diagnostic tests for NASH and fibrosis include imaging-based techniques:<\/p>\n\n\n\n<ul>\n<li>Ultrasound (NAFLD)<\/li>\n\n\n\n<li>MRI (NAFLD)<\/li>\n\n\n\n<li>Transient elastography (NAFLD, Fibrosis)<\/li>\n\n\n\n<li>Ultrasound Elastography (Fibrosis)<\/li>\n\n\n\n<li>MRE (Fibrosis)<\/li>\n<\/ul>\n\n\n\n<p>These diagnostic tools are all non-invasive, which is a major advantage to the patient, however, none of these&nbsp;general tests were originally designed to diagnose all features of NASH: fat, necro-inflammation, and fibrosis.&nbsp;Furthermore, each of these tests requires a fairly large capital investment by the physician practice which is&nbsp;why most of these techniques have limited availability for patients across the world.<\/p>\n\n\n\n<p>So not only do imaging techniques lack precision when it comes to accurately stratifying patients by disease&nbsp;stage (for instance based on NAFLD Activity Score \u2013 or NAS \u2013 and fibrosis stages, from F0 to F4), but they are&nbsp;also characterized by a limited access due to costs and to a limited number of points of care able to perform.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/www.waybackmachinedownloader.com\/scraping\/files\/live\/the-nash-education-program.com_georgenjenga69_yahoo.com_zyrp7w0mtc\/wp-content\/uploads\/2018\/03\/blood.png\" alt=\"\"\/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">TOMORROW: DIAGNOSIS WITH A SIMPLE BLOOD SAMPLE?<\/h4>\n\n\n\n<p>For many years, specialists have been using routine blood tests (e.g. liver enzymes (AST, ALT), platelets) to&nbsp;quantify a patient\u2019s risk of having liver disease. However, these general biomarkers are not sufficient on their&nbsp;own to be used as reliable diagnostic tools for NASH and fibrosis.<\/p>\n\n\n\n<p>The development of new NASH diagnostic tools is fortunately very dynamic, and some non-invasive diagnostic&nbsp;tools using blood tests are currently being developed. If the performance of these new tests is validated by&nbsp;public health authorities, these diagnostics would represent more widely available and lower-cost alternatives&nbsp;for specialists (hepatologists, gastroenterologists, diabetologists and endocrinologists) and general&nbsp;practitioners when compared to the liver biopsy and imaging-based approaches.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">ASKING FOR DIAGNOSIS<\/h4>\n\n\n\n<p>You may wonder whether you are at risk of NASH. Do not hesitate to ask your doctor for more information&nbsp;about the disease and diagnosis options. He or she may be aware of the current reference guidelines on NASH:<\/p>\n\n\n\n<ul>\n<li><a href=\"https:\/\/www.the-nash-education-program.com\/wp-content\/uploads\/2018\/01\/NAFLD-Guidance-2018.pdf\">\u201cThe Diagnosis and Management of Nonalcoholic Fatty Liver Disease: Practice Guidance From the American Association for the Study of Liver Diseases\ufffd?<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.the-nash-education-program.com\/wp-content\/uploads\/2018\/01\/English-report.pdf\">\u201cEASL\u2013EASD\u2013EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease\ufffd?<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>NASH is a silent disease. Consequently, NASH patients can remain unaware of their liver condition until the&nbsp;disease progresses to more &#8230; <\/p>\n<p class=\"read-more-container\"><a title=\"HOW TO DIAGNOSE NASH?\" class=\"read-more button\" href=\"https:\/\/www.the-nash-education-program.com\/what-is-nash\/how-to-diagnose-nash\/#more-1283\" aria-label=\"More on HOW TO DIAGNOSE NASH?\">Read more<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":16,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ub_ctt_via":"","footnotes":""},"featured_image_src":null,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.9.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>HOW TO DIAGNOSE NASH? - NASH Disease<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.the-nash-education-program.com\/what-is-nash\/how-to-diagnose-nash\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HOW TO DIAGNOSE NASH? - NASH Disease\" \/>\n<meta property=\"og:description\" content=\"NASH is a silent disease. 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