{"id":1278,"date":"2024-01-18T08:59:43","date_gmt":"2024-01-18T08:59:43","guid":{"rendered":"https:\/\/www.the-nash-education-program.com\/?page_id=1278"},"modified":"2024-01-18T08:59:43","modified_gmt":"2024-01-18T08:59:43","slug":"key-figures","status":"publish","type":"page","link":"https:\/\/www.the-nash-education-program.com\/what-is-nash\/key-figures\/","title":{"rendered":"NASH PREVALENCE: KEY FIGURES"},"content":{"rendered":"\n<p><strong>It is difficult to obtain an accurate estimate of NASH prevalence given the fact that NASH is a silent disease, and&nbsp;a disease that remains difficult to diagnose for the time being, even though promising programs are currently&nbsp;in development. But the trends are clear: non-alcoholic fatty liver disease (NAFLD) is growing to become the most common chronic liver condition in Western populations in relation to the obesity and type 2 diabetes&nbsp;epidemics, and the prevalence of NASH is also expected to increase by 63% between 2015 and 2030 (Estes&nbsp;2018). In the United States, NASH is expected to become the leading cause of liver transplantation by 2020.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/web.archive.org\/web\/20180927131250im_\/https:\/\/www.the-nash-education-program.com\/wp-content\/uploads\/2018\/03\/population.png\" alt=\"\"\/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">Prevalence in the general population<\/h4>\n\n\n\n<p>NAFLD (NON-ALCOHOLIC FATTY LIVER DISEASE)<\/p>\n\n\n\n<p><strong><em>34<\/em>%<\/strong><\/p>\n\n\n\n<p>NASH (NON-ALCOHOLIC STEATOHEPATITIS)<\/p>\n\n\n\n<p><strong><em>12<\/em>%<\/strong><\/p>\n\n\n\n<p>NAFLD prevalence in the general population has been estimated in several studies using different&nbsp;methodologies. One study based on one of the largest database in the United-States (12.317 individuals)&nbsp;concluded that 34% of the general population of the United States were affected by NAFLD (Kim 2013),&nbsp;amounting to at least 42 millions of adults. In another meta-analysis study (Younossi 2017), worldwide&nbsp;prevalence of NAFLD was estimated at 25.2%.<\/p>\n\n\n\n<p>The overall NASH prevalence in the adult population of developed countries has been estimated as high as 12%&nbsp;(Williams, 2011), with a heterogeneous repartition in relation to ethnicity:<\/p>\n\n\n\n<ul>\n<li>Hispanics: 19%<\/li>\n\n\n\n<li>Afro-Americans: 14%<\/li>\n\n\n\n<li>Caucasians: 10%<\/li>\n\n\n\n<li>Others: 7%<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/web.archive.org\/web\/20180927131250im_\/https:\/\/www.the-nash-education-program.com\/wp-content\/uploads\/2018\/03\/obesity.png\" alt=\"\"\/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">Populations at risk: prevalence in population with obesity<\/h4>\n\n\n\n<p>NAFLD is highly prevalent in populations suffering from obesity, but exact figures remain hard to estimate; in a study based on a population with severe obesity (BMI &gt; 40), more than 90% of individuals had NAFLD (AASLD&nbsp;Practice Guideline, 2012). As for NASH prevalence, a study aggregating data from more than 1.600 individuals&nbsp;who had bariatric surgery revealed a prevalence of 37% (Machado, 2006).<\/p>\n\n\n\n<p>Obesity trends: Growing to epidemic proportions over the last 30 years, obesity is&nbsp;expected to continue to keep increasing over the next decades, albeit at reduced pace. According to OECD,&nbsp;47% of adult population in the United States will suffer from obesity by 2030, compared to 37.7% in 2014. This&nbsp;represents a 25% increase in obesity by 2030.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/web.archive.org\/web\/20180927131250im_\/https:\/\/www.the-nash-education-program.com\/wp-content\/uploads\/2018\/03\/diabetes.png\" alt=\"\"\/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">Populations at risk: prevalence in people with type 2 diabetes<\/h4>\n\n\n\n<p>NAFLD prevalence in populations with type 2 diabetes is estimated at approximately 70% in several studies;&nbsp;this estimation is also used in the AASLD Practice Guidelines. Depending on the methodologies and&nbsp;populations used in the respective studies, estimations of NASH prevalence in this population range from 22%&nbsp;to 70% (Williams et al. 2011 and Bazick et al. 2015).<\/p>\n\n\n\n<p>Type 2 diabetes trends: worldwide diabetes rates are expected to grow by about&nbsp;55% by the year 2035 according to the International Diabetes Federation, which means that this population at&nbsp;risk of NAFLD\/NASH will increase dramatically over the next decades.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/web.archive.org\/web\/20180927131250im_\/https:\/\/www.the-nash-education-program.com\/wp-content\/uploads\/2018\/03\/pediatric.png\" alt=\"\"\/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">Pediatric NAFLD and NASH<\/h4>\n\n\n\n<p>Non-alcoholic fatty liver disease in children is a major health concern for the medical community. The&nbsp;phenomenon was first reported in 1983 and has since become a leading cause of childhood chronic liver&nbsp;disease which has also been fueled by the growing childhood obesity epidemic.<\/p>\n\n\n\n<p>Several studies have found that approximately 10% of the pedatric population had NAFLD, with a higher&nbsp;incidence in children of hispanic origin (Schwimmer JB et al, 2006). For example, a study conducted in the&nbsp;United States in more than 8.500 individuals estimated that 10% and 3% of US adolescents were affected&nbsp;respectively by NAFLD and NASH (Selvakumar, Pediatric Clinics of North America 2017).<\/p>\n\n\n\n<p><em><strong>\u2014<\/strong><br>References<\/em><br><em>Aguiree, F. et al., IDF Diabetes Atlas : sixth edition 2013 International Diabetes Federation<\/em><br><em>Bazick, J. et al., Clinical Model for NASH and Advanced Fibrosis in Adult Patients With Diabetes and NAFLD: Guidelines for Referral in NAFLD. Diabetes Care, 2015. 38(7): p. 1347-55.<\/em><br><em>Chalasani, N. et al., The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology, 2012. 55(6): p. 2005-23.<\/em><br><em>Estes, C. et al., Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease. Hepatology, 2018. 67(1): p. 123-133.<\/em><br><em>Kim, D. et al., Association between noninvasive fibrosis markers and mortality among adults with nonalcoholic fatty liver disease in the United States. Hepatology, 2013. 57(4): p. 1357-65.<\/em><br><em>Machado, M. et al., Hepatic histology in obese patients undergoing bariatric surgery. J Hepatol, 2006. 45(4): p. 600-6.<\/em><br><em>OECE, Obesity Update 2017. [online]&nbsp;<a href=\"https:\/\/web.archive.org\/web\/20180927131250\/https:\/\/www.oecd.org\/els\/health-systems\/Obesity-Update-2017.pdf\">https:\/\/www.oecd.org\/els\/health-systems\/Obesity-Update-2017.pdf<\/a><\/em><br><em>Schwimmer, J.B. et al., Prevalence of fatty liver in children and adolescents. Pediatrics, 2006. 118(4): p. 1388-93.<\/em><br><em>Selvakumar, P.K. et al., Nonalcoholic Fatty Liver Disease in Children Hepatic and Extrahepatic Complications. Pediatr Clin N Am, 2017. 64 (2017) 659-675.&nbsp;<\/em><em>Williams, C.D. et al., Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology, 2011. 140(1): p. 124-31.<\/em><br><em>Younossi, Z.M. et al., Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology, 2016. 64(1): p. 73-84.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>It is difficult to obtain an accurate estimate of NASH prevalence given the fact that NASH is a silent disease, &#8230; <\/p>\n<p class=\"read-more-container\"><a title=\"NASH PREVALENCE: KEY FIGURES\" class=\"read-more button\" href=\"https:\/\/www.the-nash-education-program.com\/what-is-nash\/key-figures\/#more-1278\" aria-label=\"More on NASH PREVALENCE: KEY FIGURES\">Read more<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":16,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ub_ctt_via":"","footnotes":""},"featured_image_src":null,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.9.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NASH PREVALENCE: KEY FIGURES - NASH Disease<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.the-nash-education-program.com\/what-is-nash\/key-figures\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NASH PREVALENCE: KEY FIGURES - NASH Disease\" \/>\n<meta property=\"og:description\" content=\"It is difficult to obtain an accurate estimate of NASH prevalence given the fact that NASH is a silent disease, ... 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