{"id":1219,"date":"2024-01-17T14:19:02","date_gmt":"2024-01-17T14:19:02","guid":{"rendered":"https:\/\/www.the-nash-education-program.com\/?page_id=1219"},"modified":"2024-01-17T14:19:02","modified_gmt":"2024-01-17T14:19:02","slug":"comment-diagnostiquer-la-nash","status":"publish","type":"page","link":"https:\/\/www.the-nash-education-program.com\/fr\/quest-ce-que-la-nash\/comment-diagnostiquer-la-nash\/","title":{"rendered":"COMMENT DIAGNOSTIQUER LA NASH ?"},"content":{"rendered":"\n<p><strong>\u00c9tant une maladie silencieuse et progressive, la NASH peut demeurer ind\u00e9tect\u00e9e jusqu\u2019\u00e0 ce que la pathologie ait d\u00e9j\u00e0 \u00e9volu\u00e9 \u00e0 des stades plus critiques et mettant en danger le pronostic vital. La d\u00e9tection pr\u00e9coce est l\u2019un des plus gros enjeux li\u00e9 au diagnostic et \u00e0 la prise en charge de la NASH.<sup>1-3<\/sup>&nbsp;Mais la sensibilisation et l\u2019\u00e9ducation peuvent aider \u00e0 changer cela.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/www.waybackmachinedownloader.com\/scraping\/files\/live\/the-nash-education-program.com_georgenjenga69_yahoo.com_zyrp7w0mtc\/wp-content\/uploads\/2018\/03\/syringe.png\" alt=\"\"\/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">R\u00c9F\u00c9RENCE ACTUELLE : BIOPSIE H\u00c9PATIQUE<\/h4>\n\n\n\n<p>Aujourd\u2019hui, le diagnostic est souvent formellement \u00e9tabli par une biopsie du foie. Cependant cette proc\u00e9dure invasive, bien qu\u2019actuellement la r\u00e9f\u00e9rence en la mati\u00e8re, peut \u00eatre co\u00fbteuse, inconfortable et potentiellement risqu\u00e9e pour les patients.<sup>4<\/sup>&nbsp;Le nombre de sp\u00e9cialistes capables de pratiquer et d\u2019interpr\u00e9ter la biopsie est \u00e9galement tr\u00e8s limit\u00e9, notamment au regard du nombre de patients suspect\u00e9s d\u2019\u00eatre atteints de la NASH, ce qui rend cette proc\u00e9dure impossible \u00e0 int\u00e9grer au suivi clinique standard.<sup>3<\/sup>&nbsp;En tant que telle, la biopsie du foie repr\u00e9sente une restriction significative pour l\u2019acc\u00e8s au diagnostic du plus grand nombre.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/www.waybackmachinedownloader.com\/scraping\/files\/live\/the-nash-education-program.com_georgenjenga69_yahoo.com_zyrp7w0mtc\/wp-content\/uploads\/2018\/03\/ultrasound.png\" alt=\"\"\/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">AUTRES M\u00c9THODES DE DIAGNOSTIC<\/h4>\n\n\n\n<p>D\u2019autres m\u00e9thodes de diagnostic non invasives comprennent des techniques d\u2019imageries :<sup>4-6<\/sup><\/p>\n\n\n\n<ul>\n<li>Ultrasons (NAFLD)<\/li>\n\n\n\n<li>Imagerie par r\u00e9sonance magn\u00e9tique, IRM (NAFLD)<\/li>\n\n\n\n<li>\u00c9lastographie transitoire (NAFLD, fibrose)<\/li>\n\n\n\n<li>\u00c9lastographie par ultrasons (Fibrose)<\/li>\n\n\n\n<li>\u00c9lastographie par r\u00e9sonance magn\u00e9tique, ERM (Fibrose)<\/li>\n<\/ul>\n\n\n\n<p>Malheureusement, aucune de ces m\u00e9thodes n\u2019a \u00e9t\u00e9 \u00e0 l\u2019origine cr\u00e9\u00e9e pour le diagnostic de toues les caract\u00e9ristiques de la NASH. Bien que ces techniques aient prouv\u00e9 leur efficacit\u00e9, certaines sont trop co\u00fbteuses et trop longues \u00e0 pratiquer. De plus, elles requi\u00e8rent toutes une expertise d\u2019utilisation et d\u2019interpr\u00e9tation qui les rendent difficiles d\u2019acc\u00e8s au plus grand nombre dans le cadre de soins g\u00e9n\u00e9raux, reportant ou compliquant davantage la proc\u00e9dure de diagnostic de la NASH.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/www.waybackmachinedownloader.com\/scraping\/files\/live\/the-nash-education-program.com_georgenjenga69_yahoo.com_zyrp7w0mtc\/wp-content\/uploads\/2018\/03\/blood.png\" alt=\"\"\/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">ANALYSE SANGUINE<\/h4>\n\n\n\n<p>Pendant des ann\u00e9es, les sp\u00e9cialistes ont tent\u00e9 de quantifier les risques h\u00e9patiques de leurs patients \u00e0 l\u2019aide d\u2019analyses sanguines de routine (p. ex. les taux d\u2019enzymes h\u00e9patiques [aspartate aminotransf\u00e9rase (ASAT), alanine transaminase (ALAT)], plaquettes). Cependant, ces biomarqueurs g\u00e9n\u00e9raux ne suffisent pas \u00e0 eux seuls \u00e0 fournir un diagnostic fiable pour la NASH et la fibrose, puisque typiquement, les taux d\u2019ALAT et\/ou d\u2019ASAT peuvent \u00eatre normaux chez les patients souffrant de NAFLD et m\u00eame de NASH.<sup>5<\/sup><\/p>\n\n\n\n<p>Les techniques de diagnostic non invasives, qu\u2019il s\u2019agisse de biomarqueurs sanguins ou de biomarqueurs par imagerie, sont n\u00e9cessaires de mani\u00e8re urgente pour donner l\u2019acc\u00e8s \u00e0 un diagnostic de la NASH fiable \u00e0 la grande majorit\u00e9 des populations en ayant le plus besoin.<sup>7<\/sup><\/p>\n\n\n\n<p>S\u2019ils \u00e9taient valid\u00e9s pour remplacer la biopsie h\u00e9patique, de tels biomarqueurs pourraient acc\u00e9l\u00e9rer de mani\u00e8re significative le d\u00e9veloppement de m\u00e9dicaments contre la NAFLD. La FDA encourage les sponsors \u00e0 envisager le d\u00e9veloppement de biomarqueurs.<sup>7<\/sup><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">L\u2019AVENIR DU DIAGNOSTIC DE LA NASH<\/h4>\n\n\n\n<p>Heureusement, de nouvelles techniques de diagnostic non-invasif \u00e0 moindre co\u00fbt et d\u00e9montrant une meilleure pr\u00e9cision sont en cours de d\u00e9veloppement pour la NASH. Elles devraient pouvoir fournir un acc\u00e8s plus large \u00e0 un diagnostic de la NASH fiable, dans les ann\u00e9es \u00e0 venir.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u00c9TABLIR UN DIAGNOSTIC<\/h4>\n\n\n\n<p>La mani\u00e8re de diagnostiquer la NASH \u00e9volue. Mais ce n\u2019est pas toujours simple. T\u00e9l\u00e9chargez les recommandations pratiques actuelles sur la NASH :<\/p>\n\n\n\n<ul>\n<li><a href=\"https:\/\/www.the-nash-education-program.com\/wp-content\/uploads\/2018\/01\/NAFLD-Guidance-2018.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u00ab Le diagnostic et la prise en charge de la maladie du foie gras non alcoolique : Recommandations pratiques de l\u2019American Association for the Study of Liver Diseases \u00bb<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.the-nash-education-program.com\/wp-content\/uploads\/2018\/01\/English-report.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u00ab EASL-EASD-EASO Recommandations cliniques pratiques pour la prise en charge de la maladie du foie gras non alcoolique \u00bb<\/a><\/li>\n<\/ul>\n\n\n\n<p><a href=\"https:\/\/www.waybackmachinedownloader.com\/scraping\/files\/live\/the-nash-education-program.com_georgenjenga69_yahoo.com_zyrp7w0mtc\/fr\/quest-ce-que-la-nash\/quelles-sont-les-consequences-de-la-nash\/\">QUELLES SONT LES CONS\u00c9QUENCES DE LA NASH ?<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.waybackmachinedownloader.com\/scraping\/files\/live\/the-nash-education-program.com_georgenjenga69_yahoo.com_zyrp7w0mtc\/fr\/brochures-educatives\/\">D\u00c9COUVREZ NOS BROCHURES \u00c9DUCATIVES<\/a><\/p>\n\n\n\n<p>References<\/p>\n\n\n\n<ol>\n<li>Mayo Clinic. Nonalcoholic fatty liver disease. https:\/\/www.mayoclinic.org\/diseases-conditions\/nonalcoholic-fatty-liver-disease\/symptoms-causes\/syc-20354567?p=1. Accessed October 7, 2019.<\/li>\n\n\n\n<li>Polis S, Fernandez R. Impact of physical and psychological factors on health-related quality of life in adult patients with liver cirrhosis: a systematic review protocol. JBI Database System Rev Implement Rep. 2015;13(1)39-51.<\/li>\n\n\n\n<li>Younossi, ZM, Koenig AB, Abdelatif D, et al. Global epidemiology of nonalcoholic fatty liver disease -Meta-analytic assessment of prevalence, incidence, and outcomes.&nbsp;<em>Hepatology<\/em>. 2016;64(1):73-84.<\/li>\n\n\n\n<li>Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non- alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association.&nbsp;<em>Hepatology<\/em>. 2012;55(6):2005-2023.<\/li>\n\n\n\n<li>European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO). EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease.&nbsp;<em>J Hepatol<\/em>, 2016;64(6):1388-1402.<\/li>\n\n\n\n<li>Rinella ME, Sanyal AJ. Management of NAFLD: a stage-based approach.&nbsp;<em>Nature<\/em>. 2016;13:196-205.<\/li>\n\n\n\n<li>Center for Drug Evaluation and Research (CDER). Noncirrhotic nonalcoholic steatohepatitis with liver fibrosis: developing drugs for treatment, guidance for industry, draft guidance. https:\/\/www.fda.gov\/media\/119044\/download. Published December 2018. Accessed October 11, 2019.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u00c9tant une maladie silencieuse et progressive, la NASH peut demeurer ind\u00e9tect\u00e9e jusqu\u2019\u00e0 ce que la pathologie ait d\u00e9j\u00e0 \u00e9volu\u00e9 \u00e0 &#8230; <\/p>\n<p class=\"read-more-container\"><a title=\"COMMENT DIAGNOSTIQUER LA NASH ?\" class=\"read-more button\" href=\"https:\/\/www.the-nash-education-program.com\/fr\/quest-ce-que-la-nash\/comment-diagnostiquer-la-nash\/#more-1219\" aria-label=\"More on COMMENT DIAGNOSTIQUER LA NASH ?\">Read more<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":1186,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ub_ctt_via":"","footnotes":""},"featured_image_src":null,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.9.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>COMMENT DIAGNOSTIQUER LA NASH ? - NASH Disease<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.the-nash-education-program.com\/fr\/quest-ce-que-la-nash\/comment-diagnostiquer-la-nash\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"COMMENT DIAGNOSTIQUER LA NASH ? - NASH Disease\" \/>\n<meta property=\"og:description\" content=\"\u00c9tant une maladie silencieuse et progressive, la NASH peut demeurer ind\u00e9tect\u00e9e jusqu\u2019\u00e0 ce que la pathologie ait d\u00e9j\u00e0 \u00e9volu\u00e9 \u00e0 ... 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