{"id":1186,"date":"2024-01-17T13:49:36","date_gmt":"2024-01-17T13:49:36","guid":{"rendered":"https:\/\/www.the-nash-education-program.com\/?page_id=1186"},"modified":"2024-01-17T13:49:36","modified_gmt":"2024-01-17T13:49:36","slug":"quest-ce-que-la-nash","status":"publish","type":"page","link":"https:\/\/www.the-nash-education-program.com\/fr\/quest-ce-que-la-nash\/","title":{"rendered":"QU’EST-CE QUE LA NASH ?"},"content":{"rendered":"\n

La NASH signifie\u00a0Non-Alcoholic SteatoHepatitis<\/em>\u00a0(st\u00e9atoh\u00e9patite non alcoolique).<\/strong>\u00a0Elle peut se d\u00e9finir comme la manifestation h\u00e9patique d\u2019un dysfonctionnement m\u00e9tabolique ; il s\u2019agit de la forme la plus s\u00e9v\u00e8re de la maladie du foie gras non alcoolique (Non-Alcoholic Fatty Liver Disease, NAFLD<\/em>). <\/p>\n\n\n\n

La NASH est tr\u00e8s li\u00e9e \u00e0 la triple \u00e9pid\u00e9mie d\u2019ob\u00e9sit\u00e9, de pr\u00e9-diab\u00e8te et de diab\u00e8te.1<\/sup>\u00a0Ses sympt\u00f4mes sont souvent silencieux ou non sp\u00e9cifiques \u00e0 la NASH, rendant cette maladie difficile \u00e0 diagnostiquer. Par cons\u00e9quent, les patients atteints de la NASH peuvent ne pas conna\u00eetre leur \u00e9tat avant les stades les plus avanc\u00e9s de la maladie.2,3<\/sup><\/p>\n\n\n\n

QU\u2019EST-CE QUE LA NAFLD ?<\/h3>\n\n\n\n

La maladie du foie gras non alcoolique (Non-Alcoholic Fatty Liver Disease, NAFLD<\/em>) est le terme g\u00e9n\u00e9rique d\u00e9signant un spectre de pathologies caract\u00e9ris\u00e9es par l\u2019accumulation de graisse dans le foie, depuis la st\u00e9atose isol\u00e9e jusqu\u2019\u00e0 la NASH.4<\/sup><\/p>\n\n\n\n

COMMENT DIAGNOSTIQUER LA NASH ?<\/a><\/p>\n\n\n\n

UNE MALADIE DU MODE DE VIE MODERNE<\/h2>\n\n\n\n

La NASH est largement influenc\u00e9e par le mode de vie (par ex. un exc\u00e8s chronique d\u2019apport calorique, une activit\u00e9 s\u00e9dentaire) et se distingue des autres maladies du foie gras caus\u00e9es par l\u2019abus d\u2019alcool ou les effets secondaires des m\u00e9dicaments.1<\/sup><\/p>\n\n\n\n

FACTEURS DE RISQUE<\/h2>\n\n\n\n

Les sympt\u00f4mes de la NASH sont souvent invisibles jusqu\u2019\u00e0 ce que le foie soit irr\u00e9m\u00e9diablement endommag\u00e9.2,3<\/sup> Mais la compr\u00e9hension des facteurs de risque de la NASH peut aider les patients \u00e0 risque \u00e0 obtenir le bon diagnostic.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

Hypertension<\/h4>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

MALADIE CARDIAQUE<\/h4>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

TAUX \u00c9LEV\u00c9S DE LIPIDES DANS LE SANG<\/h4>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

R\u00c9SISTANCE \u00c0 L\u2019INSULINE<\/h4>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

DIAB\u00c8TE DE TYPE 2<\/h4>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

OB\u00c9SIT\u00c9<\/h4>\n\n\n\n

QUI EST \u00c0 RISQUE DE NASH ?5<\/sup><\/a><\/p>\n\n\n\n

UNE MALADIE PROGRESSIVE ET METTANT EN DANGER LA VIE DU PATIENT<\/h2>\n\n\n\n

La NASH aggrave les affections cardiom\u00e9taboliques des patients et engendre un risque plus \u00e9lev\u00e9 de d\u00e9c\u00e8s par accidents cardiovasculaires.1<\/sup> Jusqu\u2019\u00e0 38 % des d\u00e9c\u00e8s de patients atteints de NASH sont directement li\u00e9s \u00e0 des accidents cardiovasculaires.6<\/sup><\/p>\n\n\n\n

Alors que les patients demeurent inconscients de leur trouble h\u00e9patique, la NASH peut progresser vers des complications plus graves telles que la fibrose avanc\u00e9e, la cirrhose, l\u2019insuffisance h\u00e9patique ou le cancer du foie, engendr\u00e9es par l\u2019inflammation et la d\u00e9gradation des cellules h\u00e9patiques.4<\/sup><\/p>\n\n\n\n

Aux stades les plus avanc\u00e9s de la maladie, le patient peut n\u2019avoir d\u2019autre option que la transplantation h\u00e9patique.1<\/sup> Mais cette op\u00e9ration chirurgicale \u00e0 risque peut engendrer de nombreuses complications, sans \u00e9voquer les longues listes d\u2019attente caus\u00e9es par le manque de disponibilit\u00e9 d\u2019organes sains de donneurs ou des probl\u00e8mes d\u2019\u00e9ligibilit\u00e9 li\u00e9s \u00e0 l\u2019\u00e9tat du patient.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

UN FOIE SAIN\/span><\/h4>\n\n\n\n

Le foie est le plus gros organe plein du corps et il effectue de nombreuses fonctions essentielles telles que le m\u00e9tabolisme des nutriments, la synth\u00e8se des prot\u00e9ines, la production de bile et le stockage du glycog\u00e8ne. Un foie sain est rouge sang avec une surface lisse et contient 5 % (ou moins) de graisse.1<\/sup><\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

ST\u00c9ATOSE<\/h4>\n\n\n\n

Le foie gras, ou st\u00e9atose h\u00e9patique non alcoolique, survient chez des individus consommant de mani\u00e8re chronique un exc\u00e8s de calories et\/ou avec un mode de vie s\u00e9dentaire, sans consommation significative d\u2019alcool. L\u2019exc\u00e8s de calories est stock\u00e9 dans les cellules du foie sous forme de lipides, occasionnant un foie contenant plus de 5 % de graisse et d\u2019apparence jaune p\u00e2le.1<\/sup><\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

NASH<\/h4>\n\n\n\n

Lorsque l\u2019accumulation de graisse dans le foie est trop importante, une inflammation chronique et la d\u00e9gradation des cellules (ballooning) s\u2019installent, caract\u00e9risant la NASH. \u00c0 ce stade, les patients pr\u00e9sentent un risque plus \u00e9lev\u00e9 de d\u00e9c\u00e8s par maladie cardiovasculaire.1<\/sup><\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

CIRRHOSE<\/h4>\n\n\n\n

La d\u00e9gradation des cellules et le ballooning chronique et continu engendrent l\u2019accumulation d\u2019un tissu cicatriciel non fonctionnel (fibrose). Finalement, l\u2019accumulation cicatricielle excessive aboutit \u00e0 une perte de fonction h\u00e9patique, un stade appel\u00e9 cirrhose ou fibrose de stade 4.1<\/sup><\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

COMPLICATIONS<\/h4>\n\n\n\n

Les patients atteints de cirrhose li\u00e9e \u00e0 la NASH pr\u00e9sente un risque plus \u00e9lev\u00e9 d\u2019affections h\u00e9patiques de stade terminal telles que la perte des fonctions h\u00e9patiques (d\u00e9compensation), l\u2019insuffisance h\u00e9patique et le carcinome h\u00e9patocellulaire (cancer du foie). Ils pr\u00e9sentent \u00e9galement un risque plus \u00e9lev\u00e9 de d\u00e9c\u00e8s par affection cardiovasculaire et cancers autres que cancer du foie.1<\/sup><\/p>\n\n\n\n

QUELLE EST LA PR\u00c9VALENCE DE LA NASH ?<\/a><\/p>\n\n\n\n

References<\/p>\n\n\n\n

    \n
  1. European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO). EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol<\/em>, 2016;64(6):1388-1402.<\/li>\n\n\n\n
  2. Mayo Clinic. Nonalcoholic fatty liver disease. https:\/\/www.mayoclinic.org\/diseases-
    conditions\/nonalcoholic-fatty-liver-disease\/symptoms-causes\/syc-20354567?p=1. Accessed October 7, 2019.<\/li>\n\n\n\n
  3. Polis S, Fernandez R. Impact of physical and psychological factors on health-related quality of life in adult patients with liver cirrhosis: a systematic review protocol. JBI Database System Rev Implement Rep. 2015;13(1)39-51.<\/li>\n\n\n\n
  4. Torres DM, Williams CD, Harrison SA, et al. Features, diagnosis, and treatment of non-alcoholic fatty liver disease. Clin Gastro Hepatol<\/em>. 2012;10:837-858.<\/li>\n\n\n\n
  5. Chalasani, N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology<\/em>. 2012;55(6):2005-2023.<\/li>\n\n\n\n
  6. Angulo P, Kleiner DE, Dam-Larsen S, et al. Liver fibrosis, but no other histologic features, associates with long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology<\/em>. 2015;149(2):389-397.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    La NASH signifie\u00a0Non-Alcoholic SteatoHepatitis\u00a0(st\u00e9atoh\u00e9patite non alcoolique).\u00a0Elle peut se d\u00e9finir comme la manifestation h\u00e9patique d\u2019un dysfonctionnement m\u00e9tabolique ; il s\u2019agit de … <\/p>\n

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